On Friday, First Lady Margaret Kenyatta will take Melania to visit the David Sheldrick Wildlife Trust before heading to State House for talks.
The first lady was greeted by Malawi's first lady, Gertrude Mutharika, when she arrived in the country.
Mrs Trump has also said she is looking forward to meeting her Kenyan counterpart.
"Our country's great First Lady, Melania, is doing really well in Africa".
The singing and dancing continued outside, where she read a story to the same group of children who had walked up the pathway with her.
Mrs. Trump also stopped to visit an ivory burn site, where the material has been destroyed to discourage the ivory trade.
Mrs. Trump arrived in the West African nation on Tuesday to open her first extended solo global tour.
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Despite the president's previous statement, Afful said that "she has come to see how wonderful we are".
According to Malawi State House official says Mrs Trump was looking forward to seeing how the USA can continue working together with Malawi to support a USAid programme that is focused on children's education. Upon her departure, the first lady gifted children with dozens of "Be Best" soccer balls, tote bags and school supplies.
She will finally wrap-up her four-nation tour in Egypt and Malawi. As she says, the campaign is "shining a spotlight on successful programs and organizations that teach children tools and skills".
In a tweet seen by TUKO.co.ke, the 45th president of United States said his wife was handling her first trip to the continent exceptionally well.
She was seen walking up the orphanage path holding hands with two children and led the other children sang as they marched and danced towards a shelter surrounded by journalists with cameras and security agents. "It is a handsome thing to see".