Roads across the southern portion of Iowa were snow-covered, and strong winds created risky travel conditions, according to the Iowa Department of Transportation.
Blizzard conditions are now developing in west of Chicago as the early winter storm continues to strengthen. Minor accidents have been reported along Interstate 80 in Iowa, Johnson and Cedar Counties where snow began to pile up late Sunday morning. The University of Missouri-Kansas City has canceled classes Monday due to Sunday's storm.
Nebraska State Patrol also advised motorists to avoid roads after ice and snow on motorways caused a number of vehicle spin-outs and crashes.
Most of central to northern Kansas could see 2 to 3 inches of snow, but parts of the far northeast part of the state, including the Kansas City area, could see more than six inches. That included semitrailer trucks jackknifed across the highway.
As of 10 p.m., 749 flights had been canceled at O'Hare International Airport, while 421 others were facing delays, according to the Chicago Department of Aviation.
Traffic moves west along I-70 near Lawrence, Kansas, Sunday.
Kansas Gov. Jeff Colyer issued a "State of Disaster Emergency" declaration for the winter storm.
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Her brother-in-law, his wife and son had been in the area visiting for the Thanksgiving holiday and were hoping to make it to Salina for the night.
The site reported that the majority of the cancellations are flights that were supposed to be routed through Chicago or Kansas City - two areas forecast to be hit hard by the storm. "I'm just saying prayers for them and others who have to be out on the roads".
Separately, a portion of Interstate 29 was shut down in Missouri, near the Iowa border.
With up to a foot of snow expected to fall in the northwestern part of the city and suburbs, the storm could break a 123-year-old record for biggest snowstorm in Chicago in November.
However, Newsweek reports that it set a daily snowfall record of 5.3 inches in Kansas City, noting that the previous record of 3.9 inches was set in 1895.
As this storm rapidly strengthens in the western Plains on Saturday, winds could gust over 65 miles per hour in Denver, which is likely to cause some significant delays at one of the nation's busiest airports.