It was only 1-0 at half-time but, after the interval, the floodgates opened.
Llorente's penalty claims after going down under pressure from Stephen McNulty fell on deaf ears as Ben Davies got away another attempt on goal, before Connor Jennings, James Norwood and Manny Monthe had efforts as Tranmere tried to spring a surprise.
Son Heung-min scored in the rout but will now head off on global duty with South Korea at the Asian Cup, leaving Pochettino without one of his key performers ahead of a crucial run of fixtures.
Prior to this season, Tranmere Rovers have spent the last three years having to qualify for the first round proper during their time as a non-league club while tonight's opponents Tottenham Hotspur have reached the semi-finals of the competition in both of the last two campaigns.
What does it mean?
Ultima Thule: Clearest image yet of 'snowman' space rock released by NASA
As well as being the most distant object reached, Ultima Thule may be the oldest celestial object to be studied by a spacecraft. The first color image of Ultima Thule, taken at a distance of 137,000 km (85,000 mi) at 04:08 am UTC on January 1st, 2019.
"Eriksen is important to Tottenham".
Tottenham are through to the fourth round of the FA Cup in style. However, having spent almost a month on the sidelines with a groin injury, the Ivory Coast worldwide relished meeting Tranmere's combative approach head on.
"The most important thing is that we showed good mental strength", said Mauricio, who is yet to lose a game against lower league opposition. But errors and missteps peppered his display here, with Son and Lucas' livewire running proving too much to handle.
Tottenham began the game as they did against Cardiff City by dominating the possession and nearly opened the scoring within the first 10 minutes.
- Son has been directly involved in 12 goals in his past six games for Tottenham in all competitions (seven goals, five assists), as many as his previous 31 combined prior to this.