Mayfield had trimmed a 13-point deficit to two and had the Browns on the march, but C.J. Mosley tipped and picked a fourth-down pass with 62 seconds left to seal the win.
The Ravens went 9-7 but were eliminated from the playoffs in Week 17 a year ago in a win-and-in situation vs. the Bengals by surrendering a 49-yard touchdown on fourth-and-12 from Andy Dalton to Tyler Boyd on the game's final play.
The Browns take on the Baltimore Ravens at M&T Bank Stadium in Baltimore for the last game of the season on Sunday.
Mayfield made impressive throws all night, but he also showed his rookie side with the three interceptions.
Jackson is quickly causing problems for Cleveland's defense in this game and it's only the first half.
Despite the loss, the Browns won seven more games than past year and finished with their best record since 2007, their most recent winning season.
North Korea warns of 'new path' if United States 'continues to break promises'
The annual New Year's address is a tradition Mr Kim picked up from his grandfather, founder of the communist country, Kim Il-sung. After months of bitter acrimony and public name-calling between the two leaders, Trump and Kim met in Singapore in June .
Baltimore Ravens cornerback Jimmy Smith is having himself a day against Cleveland Browns quarterback Baker Mayfield. The Browns took a major risk drafting the prolific, but undersized, quarterback from Oklahoma first overall, but they clearly don't have many reasons to think they made a mistake so far. "They were disrespectful, selfish and their behavior was unbecoming that of a professional football player", the team executive said in a statement after the game.
Again, you can criticize a lot of what he does, but there's no doubt he can make plays.
The second-year corner has played up to an All-Pro caliber level this season but didn't provide one of his best performances against the Browns. The problem was, it cost Peppers a fumble recovery for a touchdown that would've pulled the Browns to within 20-14 just before the half. The Jets said goodbye to Todd Bowles, who went 24-40 over four years.
The Browns produced a sensational goal-line stand in the second quarter after Mayfield's second pick, but the officials cost them a TD by blowing the whistle too soon.
First up, former Ravens wide receiver Breshad Perriman. Sebastian Janikowski got them off the hook by making a 33-yard field goal to hand the Cardinals their league-leading 13th defeat and put them on the clock for the April 25 draft. With help of a 68-yard touchdown run, the Giants back joined Eric Dickerson and Edgerrin James as only the third rookie to gain 2,000 yards from scrimmage. Flacco was behind center in 2012, when Baltimore captured its last division crown and ultimately won the Super Bowl.