Jimmy Connors is the other male player to reach the 100 title milestone, and he ended his career on 109 titles.
Martina Navratilova holds the all-time record with 167 women's singles titles during her career.
"As for records, we live in an age where every record has to be shattered, but not for me.We'll see how much more I have left in the tank, but reaching 100 is a dream and tonight was a very special evening, but it's not about breaking every single record", he said.
It was the 18th consecutive best-of-three final that Federer won when he won the first set.
Twelve months after he made Dubai debut in 2002, Roger Federer was back in the desert as the top-10 player and Masters 1000 champion, standing as one of the favorites and defeating Jiri Novak 6-1, 7-6 on March 2, 2003, for his sixth ATP title.
Federer was edged out in four sets by Tsitsipas in Melbourne in January, which was their only previous meeting, but the Swiss veteran proved a level above his 20-year-old Greek opponent on Saturday. My family, they all support me for so, so long and I can't thank them enough.
"Yeah, I just think I played the right way".
Donald Trump announces executive order to protect free speech at colleges
He referred to House Intelligence Committee Chairman Adam Schiff, a California Democrat, as "Little Shifty Schiff". Trump " - and according to the Daily Beast , it was aimed at offsetting books deeply critical of the President.
In Saturday's final, an aggressive Federer played ideal tennis, breaking once in each set, attacking from inside the baseline and showing flashes of brilliance at the net.
Tsitsipas said: "He was very aggressive, didn't give me any time. I have loved every minute", Federer said.
"I would like to personally congratulate him for the 100". Tsitsipas came into the title round here having won eight straight matches in successive weeks of competition, his body aching and spirit sagging, but he had the numbers working for him. Coming back outdoors after getting used to playing all my matches in indoor conditions, I'm pretty happy and satisfied that I managed to make the final.
"It felt like he was controlling everything on his own terms".
Federer broke serve in the first game and took the first set on his fourth set point.
Still on a high after that success in the French capital, Federer faced an almighty battle to regain his Wimbledon title and claim a record 15th major as Andy Roddick pushed him all the way in a classic final.