The London-based man was cured of AIDS after receiving a bone marrow transplant from a HIV-resistant donor.
Blood cells of an infected person are replaced by someone who is immune to HIV through a genetic mutation which stops the virus attaching to cells.
But it in the past 18 months he was taken off the extra drugs and regular testing confirmed his viral load is now undetectable.
In the new case, now dubbed the "London patient", the anonymous male also received a stem cell treatment from a donor with the same CCR5 gene mutation, this time while being treated for Hodgkin's lymphoma.
Timothy Ray Brown, an American man then living in Germany and widely known as the "Berlin patient," underwent a similar procedure in 2007 and is reportedly still HIV-free.
It was only in 2016 that he was able to access the stem cell donation because he was seeking treatment for the cancer, not the HIB.
In some of the past transplant failures, the donor did not have a mutated CCR5, but the conditioning regimen seemed to have significantly reduced the "reservoirs" of cells in the recipient that have latent HIV infections, invisible to the immune system.
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A second person is in sustained remission from HIV-1, the virus that causes Aids, after ceasing treatment and is likely cured, researchers were set to announce at a medical conference Tuesday. In interviews, most experts are calling it a cure, with the caveat that it is hard to know how to define the word when there are only two known instances.
Most people with the HIV-resistant mutation, called delta 32, are of Northern European descent. "We need to understand if we could knock out this (CCR5) receptor in people with HIV, which may be possible with gene therapy", he said.
Compared to Brown, the London patient had a less punishing form of chemotherapy to get ready for the transplant, didn't have radiation and had only a mild reaction to the transplant.
"The cost benefit of the prognosis following a bone marrow transplant versus that on HIV antiretroviral therapy needs serious consideration", says Professor Anthony Kelleher, Director of the Kirby Institute at UNSW Sydney. "It's too early to say he's cured", he said.
However she said the process was not yet applicable to tens of millions of other HIV-infected individuals worldwide.
Gupta's patient, a male resident of the United Kingdom who prefers to remain anonymous, was diagnosed with HIV infection in 2003 and began antiretroviral therapy in 2012.
Scientist are increasingly hopeful that cure would be found soon after over 30 years of rigorous research.
The London patient has not been identified.