He took his tally for the club to 69 - a record for a Liverpool player in his first century of games.
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The England midfielder nearly made it a dream comeback when he had a chance moments after coming on and Mane headed onto the post soon after.
Determined not to be outdone by his team-mate, Salah helped himself to his second with seven minutes remaining, adding further gloss to an exceptional performance.
Having made it seven league wins in a row, Liverpool are in pole position once more.
Barca will get their hands on a 26th title if they beat Levante at the Nou Camp and could have the crown guaranteed before kickoff if Atletico Madrid lose to Real Valladolid earlier on.
- The Reds have won 10 consecutive matches in all competitions, their best winning run since May 2006 when they won 11 on the bounce. Huddersfield has lost its last seven Premier League matches, with its last win coming February 26 over Wolves-one of just three wins it has on the season.