The main region at risk for severe weather is the area along a line between Dixon and Crystal Lake, according to the weather service.
York County could see gusty winds, possible rain and thunderstorms, and localized flash flooding.
The system has so far produced tornadoes, strong winds and heavy rains from the Ohio Valley to the central Gulf Coast this week.
Radar readings appeared to show a tornado formed in the western Virginia county of Franklin south of Roanoke, though damage on the ground still must be assessed, said National Weather Service Meteorologist Phil Hysell.
Garner, Clayton and Knightdale are under a severe thunderstorm warning until noon, the National Weather Service says.
Two other people who were killed while driving as severe weather moved through the South are also being counted as storm related deaths in Mississippi. That outbreak damaged more than 250 homes, businesses and public buildings across Mississippi.
Alabama authorities said a woman was killed Thursday night after strong storms knocked a tree onto her mobile home in St Clair County.
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The storms are expected in Macon by 5 a.m. and will linger for most of the morning. When tornado warnings are issued, people should take action to protect themselves, the service says.
"Wind gusts up to 50 miles per hour will be possible with this storm", the NWS stated.
The higher the temperature is in the afternoon, the greater the chances are for severe weather, according to the evening briefing.
National Weather Service forecasters say they believe multiple tornadoes have hit the southern half of MS as a storm system moves east. There were no immediate reports of any damage from those storms, but the tornado threat was expected to continue well into the day in the Carolinas and Virginia.
Three days of severe storms in the South and Southeast are about to give way to a nice holiday weekend for much of the country.
The same storm system was blamed for the deaths a day earlier of three people in MS and a woman in Alabama.