She made her return to Grand Slam competition in Paris a year ago after missing five majors because of the birth of her first child.
The Dane had retired from her previous two matches with a persistent calf issue and that lack of match sharpness eventually cost her in a 0-6, 6-3, 6-3 defeat to 22-year-old Russian Veronika Kudermetova.
Naomi Osaka made a terrible start to her French Open campaign as the world number one was bagelled by Anna Karolina Schmiedlova in the first set of her first-round match.
Paris: Japan's Naomi Osaka admitted she has "never been so nervous" after coming within just two points of a sensational first round Roland Garros exit on Tuesday.
However she was denied as Osaka brought it back to 5-5 and then 6-6 as neither player was able to hold their serve.
"Definitely wasn't the best match I've ever played", said the 13th-seeded Wozniacki, who had only 15 winners to Kudermetova's 40.
At one stage, she was just two points away from a famous victory.
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Khan was looser and more forthcoming during this media scrum than he was in interviews prior to the pay-per-view. If you're looking to watch the entire main card for Double or Nothing you'll have a few options.
The clay courts of Roland Garros host the second Grand Slam of the season. "I was like, 'You got to do something, '" Williams said.
He is the oldest man to win a Grand Slam match since Ken Rosewall in 1978.
Tiafoe made the round of 64 at the US Open and the round of 32 at Wimbledon.
"But these are nice emotions and I am happy I could win the match and get to play another one".
After 14 unforced errors in the first set alone, she had six in the second, four in the third.
Naomi Osaka uses a plethora of quirky strategies when playing to win tennis' biggest tournaments, including slapping her leg, covering her head with a towel and, one that's come to the forefront more recently: speaking success into existence. The third set went quickly.
As she got going, Osaka delivered a pinpoint cross-court forehand that was too hard to handle, then looked at her box again, this time with a pumping clenched left fist.
"You could see", Schmiedlova said, "that she's No. 1, there".