Spurs held out for the vast majority of the second half but were undone in stoppage time when Nathan Ake headed home the victor from a corner.
Tottenham's task was made all the more hard two minutes before the interval when forward Son Heung-min was sent off for pushing Jefferson Lerma and halftime substitute Juan Foyth lasted 125 seconds before seeing red for a lunging tackle.
The result means that they stay third in the league table and have lost six consecutive league away games. But Nathan Ake headed home from a corner in the 91st minute to finally break through for Bournemouth, as they secured a first-ever league win against Tottenham. With the players Tottenham have got that shouldn't be the case, so that's a huge disappointment.
Despite their unbelievable lack of discipline Tottenham nearly held on for a crucial point in their top four battle, but Nathan Ake's 91st minute header sealed their sixth-straight PL away defeat.
"Anything still could happen".
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The Lilywhites' terrible Premier League form - the club has won just three of its last 10 in the top-flight - has repeatedly stopped them from putting the top four battle to bed and it continued today with a 1-0 defeat at Bournemouth.
With the win the Cherries moved up to 12th in the table on 45 points, while Spurs are now only four points ahead of Arsenal in fifth with one game to go, as the Gunners have a game in hand on them too.
Pochettino's side weren't clinical enough when they had the chance to kill the game in the first-half and ultimately a lack of discipline cost them.
Certainly not the ideal preparation for a Champions League semi-final that your team are losing.
Spurs head to Amsterdam trailing 1-0 from the first leg, and with injuries piling up and Tottenham winning just four of their last 15 games in all competitions, yet another fine season is threatening to end on a sour note.
Craig Pawson showed the red and Spurs were down to nine men.