"You have to know you're going to have this that of analysis and scrutiny and I think it would be helpful when they nominate people they have some of those conversations ahead of time", he said.
Moore did not respond to a request for comment from CNN on Monday.
U.S. Senate Democratic leader Chuck Schumer said the White House should immediately withdraw Moore from consideration for the seat.
The unorthodox advice - more in line with what economists on the far left of the political spectrum might advocate - is likely to go unheeded by a central bank that views its current target interest rate as roughly where it should be to keep the growing USA economy on an even keel.
Republicans had previously been publicly neutral on Moore, a longtime fixture in conservative Washington circles who was a longtime Wall Street Journal editorial board member.
Microsoft reports £23.7bn in Q3 2019 revenue
The company once relied on its Windows operating system for much of its revenues, but this now accounts for just 18% of its sales. Microsoft's intelligent-cloud unit recorded the biggest growth of the quarter, up some 22 percent from the same period of 2018.
"I don't want to be a liability", said Moore in the interview. I mean, I just love that one.
Moore's pending nomination has also drawn sharp criticism over his lack of traditional credentials and his close ties to the President, including from Massachusetts Democratic Sen.
"There are very few cases where the nominees are so blatantly political and blatantly unqualified", said Alan Blinder, an economics professor at Princeton University and a Fed vice chairman under President Bill Clinton. Republicans control the Senate 53-47.
Volcker threatened to resign after the pair outvoted him on a key interest rate decision, but ultimately he got his way.
As such, much of Moore's past writing and commentary is coming under renewed security from both an administration cautious to avoid controversial and potentially failed nomination and critics looking for evidence of why he may not be suitable for such an important role.
Thune added that there is a lesson in this for the White House about how to handle future nominations. "The Fed is to depoliticize to the extent you can".
In a tweet, the president said that the economy, while doing well, would do even better if the Fed started cutting rates and provided "some quantitative easing", referring to the process the Fed used following the financial crisis to purchase bonds to lower long-term interest rates.