Elsewhere, excitement abounds over the Next, Next Generation after 15-year-old Coco Gauff and 18-year-old Felix Auger-Aliassime both got their first Grand Slam match wins.
Emotions were mixed, her mother told CNN. "But you never know what happens".
This was her third tour-level match; Williams has played more than 1,000. "I loved tennis. I was so-so about it in the beginning because when I was younger I didn't want to practice at all".
Gauff will play Magdalena Rybarikova in the second round on Wednesday. I'd never played on a court that big and the crowd was really wild.
A glum Venus Williams sits between games during her shock loss on Tuesday.
"Of course, when you're a competitor, when you go out there, your job is to win", Candi Gauff said.
"On the court, I was not thinking about Venus - I was just playing my game", Gauff said. "You don't see that often, because it's very rare to see someone under the spotlight that early, and usually even players who are 15, 16, 17 when they start to have that pressure, majority don't do well with that". "I wouldn't be here if it wasn't for her", Gauff said.
Naomi Osaka crashes out with first round defeat at Wimbledon
Since winning the Australian Open in January, Osaka's best showing in nine tournaments was making the semifinals in Stuttgart. The court is set for Kazakhstan's Yulia Putintseva and Japan's Naomi Osaka's first-round match at Wimbledon.
The second-seeded Osaka, who won the U.S. Open last year and the Australian Open this year, was ranked No. 1 in the world until last week.
"And then the next tournament I played was French Open and I ended up winning it, maybe that had something to do with it but I mean, how could you not listen to the greatest of all time?" said Gauff.
"She is definitely a favorite of ours", Delray Beach Tennis Center general manager Jeff Bingo told UPI. "She's the reason why I wanted to play tennis and the reason why my dad made a decision to get me a racquet".
However, she did have a slight wobble at the end when she let slip three match points.
Serena Williams - who along with Venus was the inspiration for her to take up a racquet - sees something similar in Gauff's father coaching her just as as their father Richard coached them from the age of four. I can't help but look inside of myself and be proud and be happy for her.
"The pros who have been here for a long time, they're serious". She did just that, converting her fourth when Venus put a forehand into the net.