The show's original creator, Terri Minsky, is set to executive produce the reboot.
The sequel news and more details are expected to be announced at the Disney+ showcase now going down at Disney's D23 expo in Anaheim, California, so stay tuned!
ET adds that while Lizzie is an adult, she still will have 13-year-old Lizzie "blabbering around in her head".
The show will reportedly center around an all ground up Lizzie living in New York City. It also included the 2003 film, The Lizzie McGuire Movie, where Lizzie went on a trip of a lifetime in Rome, Italy, after her graduation.
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"Lizzie McGuire" was produced by Stan Rogow Productions and Disney Channel Original Productions, and distributed by Buena Vista Television. Though I wonder where the conflict will be if Lizzie has such a ideal life? The fun twist was that her travails were often commented on by an animated alter ego, who would frequently break the fourth wall with witty retorts.
It is unclear whether the other Lizzie McGuire cast members Lalaine, Adam Lamberg, Jake Thomas, Hallie Todd and Robert Carradine will return.
Duff additionally confirmed that the animated alter ego of Lizzie's inner thoughts will return.
The series followed 13-year-old Lizzie as she navigated friends (like her besties, Miranda and Gordo), family (including younger brother Matt) and teen issues, such as first loves.
Duff, who now stars on TV Land's Younger, confirmed to ET last December that there have been "some conversations" about a Lizzie McGuire revival, saying at the time, "It's definitely not a go".
The original Lizzie McGuire series ran for two seasons on the Disney Channel between 2001 and 2004.