MacFarlane also won in the category in 2016 and 2017 and received an Emmy in 2000 for outstanding voice-over performance, a juried award where there would be multiple or no recipients in one year.
Kirby won for his turn as Lenny Bruce on "The Marvelous Mrs. Maisel", in which the late NY comedian is reimagined as a mentor to housewife-turned-emerging comic Midge Maisel, played by Rachel Brosnahan.
Game of Thrones is the hot favourite in the Outstanding Drama Series category and is looking to equal the record haul of four Emmy Awards wins.
Bradley Whitford and Cherry Jones took home trophies in guest acting categories for "The Handmaid's Tale".
Rare Harvest Moon will make Friday the 13th extra 'spooky'
According to Newsweek , a full moon appearing on Friday the 13th is rare, and it won't happen again for another 30 years in 2049. It is actually quite rare for the whole of the United States to experience a full moon on the date of Friday 13.
Amazon's The Marvelous Mrs. Maisel won six awards including Outstanding Guest Actor in a Comedy Series for Luke Kirby and Outstanding Guest Actress in a Comedy Series for Jane Lynch.
Corden won two Emmys as a producer Saturday, for "Carpool Karaoke: The Series", the victor for outstanding short form variety series, and outstanding pre-recorded variety special, "Carpool Karaoke: When Corden Met McCartney Live From Liverpool". The mixing team was led by rerecording mixers Onnalee Blank and Mathew Waters, who each grabbed their fifth Emmy, as did production mixer Ronan Hill. d headed the sound editing team, and each earned their second Emmy for the series.
The first-time nominee upset some serious heavyweights in the category, including fellow "Maisel" actor Rufus Sewell, "Veep" actor Peter MacNicol, and "Saturday Night Live" performers Adam Sandler, Robert De Niro, Matt Damon, and John Mulaney. Costume supervisors Emma O'Loughlin and Kate O'Farrell were also awarded. Nanette, lesbian comic Hannah Gadsby's TedTalkish standup special for Netflix, won writing for a variety special.
Ms Oh, who is now 0-for-8 at the Emmys, will get another crack at it next week - she is once again nominated for best actress in a drama for "Killing Eve", and many prognosticators believe she is the favourite to grab that first award.
In reality TV categories, RuPaul won his fourth consecutive Emmy as reality host on VH1's "RuPaul's Drag Race".
First on the 2019 awards agenda is the Emmys, which will air live on Sunday, Sept. 22 on Fox at 8 p.m. ET.