The strike shut down 33 manufacturing plants in nine states across the USA, as well as 22 parts-distribution warehouses.
The strike - from midnight (04:00 GMT) on Monday - is the first at GM, America's biggest carmaker, since 2007.
The UAW and GM said talks would resume at 10 a.m. on Monday. "Our goal remains to build a strong future for our employees and our business", the company said.
GM workers are reportedly looking to negotiate modifications to their base pay which would prove to be assured income rather than gambling on profit-sharing incentives. "Someone will be here 24-7", said GM worker Arthur Espinoza. Steep discounts were offered to consumers this summer to sell the remaining cars and hatchbacks. Trump has attacked GM for Barra's decision to stop building small cars at an assembly plant in Lordstown, Ohio.
The company did not say what the solution would be. According to UAW spokesman Brian Rothenberg, "But basically, when the morning shift would have reported for work, they won't be there. Now we are standing together in unity and solidarity for our Members, their families and the communities where we work and live", said UAW Vice President Terry Dittes. GM was picked because it's the most profitable of the three, and because its plans to close four US factories have angered union members.
Protecting jobs and saving those plants have been key issues in the negotiations.
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GM released a statement saying it has already offered "best in class wages and benefits", a payout for every employee after the new contract is ratificatied, and promised new investments and jobs in some existing factories.
She has been at GM for 8 years. GM would not give a precise number. The network is available in more than 80 million homes in all markets across the United States.
On Friday, union leaders extended contracts with Ford and Fiat Chrysler indefinitely, but the pact with General Motors is still set to expire Saturday night.
In the strike announcement, the UAW said the strike is an effort to have GM and the other United States automakers recognize "contributions and sacrifices that the company's UAW members have made to create a healthy, profitable, industry". In its statement, the automaker said its offer to the union included solutions for the MI and OH assembly plants that now lack products.
This year's talks had been expected to be contentious but have been complicated by recent developments in a long-standing federal investigation into corruption at the union. The union has not responded to a request for comment about that report.
On Sunday, about 200 plant-level leaders voted unanimously to strike against GM if no deal could be reached by Sunday night. Four years ago the deals all passed by only narrow margins, even though there was no scandal at that time.
Prior to the call for a strike, GM bulked up its stock on trucks and SUVs just in case.