Ariana Grande came in fourth for the decade.
Spotify announced Tuesday that Drake has been streamed 28 billion times in the last 10 years.
Ed Sheeran was No. 2 on Spotify's list of most-streamed artists globally between 2010 and 2019.
You will have access to jam to your top music of the decade for the next 12 months.
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Not surprisingly, global megastar Ed Sheeran appears on the list more than once- the singer, whose paternal grandparents live in Gorey, Co Wexford, clinched the honour of the most-streamed song of the decade with his infinitely catchy Shape of You.
Drake's One Dance featuring Kyla and WizKid, Post Malone's Rockstar featuring 21 Savage, The Chainsmokers' Closer featuring Halsey, and Sheeran's Thinking Out Loud complete the top five songs. "Señorita" from Shawn Mendes and Camila Cabello topped the most-played songs, accompanied by "bad guy" from Billie Eilish, and "Sunflower" from Post Malone.
Spotify is joining the end-of-year and end-of-decade list-making party.
Eilish's album When We All Fall Asleep, Where Do We Go was the most streamed album of the year. In second and third place were Billie Eilish and Ariana Grande.
The company's rise to power - today counting 248 million monthly users, including paying and non-paying members - largely came on streaming's growing dominance in the industry. With more than 1 billion streams, it was the year's most-streamed song.