Responding to concerns on social media just after the loud bang at 4:20am, Metropolitan police urged calm.
Meanwhile, Hertfordshire Fire and Rescue Service said it had received "a large number of calls from across the whole of Hertfordshire regarding a large explosion sound".
But the thousands of residents who were awakened by the sound across north London and the Midlands at around 4.20 a.m. did not know that - and made a frenzy of emergency calls to authorities to report an apparent explosion that had made their homes shake.
The initial tweet said: "We are aware of reports of a loud bang in the north London area".
Authorities have said a loud noise heard on Sunday morning was a "sonic boom" caused by Royal Air Force planes. "There is no cause for concern".
Twitter user Natasha wrote: 'Correct been woken up by a massive explosion in North West London.
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'There are no reports of an explosion and police are wanting into the incident.
In a statement, an RAF spokesperson explained that two fighter jets had been deployed due to an unresponsive aircraft.
The UK Ministry of Defence later tweeted that the two typhoon aircraft were scrambled "after an aircraft lost communications in the UK airspace".
"RAF jets are only given permission to go supersonic in emergencies, usually when they are required to intercept another aircraft".
A sonic boom is caused when aircraft break the speed of sound.
They added the Typhoons returned to their base afterwards.
The noise is often heard as a huge thunderclap.