Wolves can consider themselves unfortunate to be the victims of Liverpool's 22nd win in 23 league games after making life as uncomfortable as anyone has for Jurgen Klopp's side this season before Firmino ensured Liverpool took another significant step towards their first title in 30 years.
Up until that unfortunate moment Mane had been largely anonymous for The Reds; having not made a single attempt on goal though he did manage to create a single goalscoring opportunity.
"When was the pressure higher on us, this year or last year?"
However, Jordan Henderson handed the visitors the lead in the eighth minute with an unstoppable header from a Trent Alexander-Arnold's corner kick from the left flank. The Brazilian intentional was in superb form before his injury and we could see him recalled to start in the holding role tonight.
And this season, Arnold has continued with his superb performances for Liverpool who are now topping the Premier League standings.
Asked if that was the toughest game Liverpool had been given in the Premier League this season, Klopp added: "No".
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Klopp intends to rotate his team much as he did for the third-round win over Everton, with Adrian set to start in goal, but he fears the game will come too soon for Xherdan Shaqiri and James Milner to be involved. I didn't think about it, I know we play Sunday at Shrewsbury [in the FA Cup], I know we play Wednesday at West Ham and I know we play Saturday. We don't go for perfection.
Oxalde-Chamberlain has put in some encouraging performance in recent games but Klopp may want to field a slightly more compact midfield away to a risky Wolves side so the former Arsenal man may have to settle for a sub role.
"He's exactly the player we expected to get", he said. They're a good team, they make you work. Their own fans are singing: "Now they're going to believe us!".
The Liverpool boss had no update on Mane's condition when speaking to reporters on Friday ahead of the FA Cup fourth-round trip to Shrewsbury Town, but he appeared confident Minamino could fill in where required.
"Defensively we were organised and we played good".