Mayweather was an excellent boxer himself, a two-time world champion nicknamed "Black Mamba", who had bouts with Julio Cesar Chavez and Ray "Boom Boom" Mancini.
"Roger was a great champion and one of the best trainers in boxing", the retired former five-weight world champion said.
In 2018, Roger Mayweather's brother, Jeff Mayweather, spoke extensively about his brother's health issues.
Details of death: Died at the age of 58. One user posted a video from Roger Mayweather's 1983 fight against Benedicto Villablanca and called it "one of his most iconic wins with a 1st round KO over Villablanca to retain the Ring, Lineal and WBA super featherweight titles".
Mayweather Jr spoke about his uncles' poor health in a 2015 interview, stating that years of boxing had taken its toll on his uncle.
Roger Mayweather also had his share of in-ring success.
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Roger had 72 professional fights from July 1981-May 1999, compiling a record of 59-13, including 35 knockouts. It is a awful loss for all of us.
"We thank you all for the outpouring of love and support during this time".
What caused the death of Roger Mayweather is still unknown.
Last week, Josie Harris, the mother of three of Mayweather's children, was found dead in her auto in front of her house in Valencia, California.
He later transitioned to training Floyd Mayweather Jr. and helping his nephew rise to prominence.
Floyd responded by posting a series of photos of the couple on Instagram as a tribute to her.