"The young brother was not happy with the situation and then Eric. did what we professionals can not do, but did something that probably we would do", Mourinho said post-match, according to ESPN.
"I don't think that belongs to the game".
The game ended in 1-1 and went down 2-3 on penalties thanks to the heroics of the Canaries goalkeeper Tim Krul.
When asked if the Argentine could be a candidate to replace Mourinho, the 33-year-old said: "Yeah, why not?"
"I think Eric did what we professionals can not do but probably every one of us would do", he told reporters after his side's fourth successive defeat.
Spurs visit Burnley tomorrow evening in what is a vital match in their bid to reach the Premier League top four, before heading to RB Leipzig needing to overturn a 1-0 deficit to keep their Champions League hopes alive.
"I was expecting players not exhausted to give more to the team and I think somebody [Ndombele] has to realise this is the Premier League".
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"But I repeat, probably everyone of us would do", he said, adding "I am with the player and I understand the player".
"I've backed him over the fact he's lost Harry Kane and Heung-min Son and he's trying to find a way to win and it hasn't quite happened".
Mourinho was drafted in to replace Pochettino back in November, following a poor run of form which had left Spurs languishing in the bottom half of the Premier League table.
"He did a back four and was so good again, so now we have the feeling that maybe his best position, and again, more important than what I feel and data shows, is what the player feels".
"I said, "I haven't seen many penalties from you when I've done my homework" and he just looked at me".
"I don't have one single negative feeling towards my players, the opposite, they tried fantastic things".