Ramaphosa, who has been under pressure from rival political parties and a variety of industries to ease the restrictions, said following broad consultations the cabinet had made a decision to move the country to "level three" of its five-level lockdown system.
According to the Presidency, Ramaphosa's address follows recent meetings of Cabinet, the National Coronavirus Command Council and the President's Coordinating Council, which considered the prospects for the country's progression from Alert Level 4 to Alert Level 3 of the national lockdown.
Under Level 3, 33% of the student population can return to tertiary education campuses, delivery sites and residences, announced Minister of Higher Education, Science and Technology Blade Nzimande at a press briefing on Saturday, 23 May.
Ramaphosa said: "Alcohol may be sold for home consumption only under strict conditions, on specified days and for limited hours".
Most sectors of the economy will be able to reopen fully under "strict health protocols" and "social distancing rules".
"The sale of tobacco products will remain prohibited in alert Level-3 due to the health risks associated with smoking", he said. E-commerce will continue to remain open.
All gatherings will remain prohibited, except for funerals with no more than 50 people or meetings in the workplace for work purposes.
Personal care services, including hairdressing and beauty services will also remain closed.
Accommodation and domestic air travel will return for business travel only, and will be phased in on dates that will be announced, Ramaphosa said.
Other sectors which can not reopen include conferences, events, entertainment and sporting activities.
Those over 60 and those who suffer from conditions such as heart disease, diabetes, chronic respiratory disease and cancer should "ideally" stay home, Ramaphosa said.
Employees who can work from home should be allowed to do so.
The whole of South Africa will move to level-3 of the lockdown on 1 June, though various hotspots - including Pretoria, Johannesburg, Cape Town, Port Elizabeth, Durban and the south coast of KwaZulu-Natal (iLembe municipality), have been identified as coronavirus "hotspots". If you develop any symptoms contact your doctor or clinic, they will advise your next steps.
New York Times devotes front page to listing a thousand coronavirus victims
The United States has been the hardest-hit country in the coronavirus pandemic by far, in deaths and number of infections. It marks the first time in living memory that the paper has had a front page without any photos or graphics.