In April, Birx claimed that the USA was "putting out the embers" of COVID-19, likening the country's reopening to that of Italy, which squashed the virus.
Birx pushed back against the Democratic lawmaker's characterization of her on the same day in a CNN interview, stating "I have never been called Pollyannish or non-scientific or non-data-driven" and confirming that the virus is "extraordinarily widespread".
Appearing on CNN's State of the Union, Birx said that the coronavirus has spread into more rural communities, rather than being contained in large metro areas, as cases have surged particularly in the southern and western states.
In response to Pelosi's criticism, Birx said "I have tremendous respect for the speaker, I have tremendous respect for her long dedication to the American people".
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Birx said that all Americans, no matter where they live, should follow the guidelines of wearing masks, practicing social distancing and maintaining good hygiene, such as regular hand washing.
The United States leads all nations with 4,620,502 cases and 154,449 deaths, according to data collected by John's Hopkins University. It's into the rural as equal urban areas", adding that "It's not super spreading individuals, it's super spreading events and we need to stop those.
The latest national ensemble forecast, published by the Centers for Disease Control and Prevention, predicts the USA could record as many as 182,000 total deaths by August 22, just three weeks away. "Each of these responses have to be dramatically tailored", she said. "We definitely need to take more precautions", Birx said.
If people wear masks and avoid crowds, Mr Giroir said, it gives the same outcome as a complete shutdown.