The Netherlands global was clattered by Toffees goalkeeper Jordan Pickford in the first half, with suggestions the challenge could have warranted a red card or a penalty to the Reds, despite Van Dijk coming from an offside position. "I hope that he can recover well and soon".
That certainly looked to be case just moments after Mane had given Liverpool the lead, as Pickford hacked Van Dijk down in the penalty area.
This would come as a huge blow to Liverpool, with the Dutchman not missing a minute of Premier League football since September 2018, a run that stretching 74 games. "They are that outstanding".
"We have no power there, we just sit here and now you discuss it with me".
It is impossible to sugar-coat the magnitude of this news, given Van Dijk's vast importance at Liverpool.
"For Jurgen Klopp and the club, right away it's who can we get in?" They defeated Newcastle United 4-1 at the Old Trafford.
With a man advantage following Richarlison's dismissal in the 90th minute, Liverpool pressed to find the victor and thought it had secured all three points at the death. While it was questionable goalkeeping from Adrian, van Dijk's presence may also have been missed.
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Without the Brazilian in goal, Klopp's men have conceded nine times in their last two matches, including a historic 7-2 humiliation at Aston Villa two weeks ago.
Van Dijk was in the Everton box in the sixth minute because of a corner, with Liverpool having already taken the lead, when Fabinho lifted the ball towards the far side of the box.
A share of the spoils means Everton remain three points clear of their city rivals at the top of the table. Everton travel to Southampton in the Premier League next Sunday.
After his surgery, Van Dijk will start a rehabilitation programme.
He was not happy with the challenges that were being thrown in by Everton's players at Goodison Park.
Thiago was able to complete the game, but has also been sent for scans to discover the extent of a knee injury.
We saw what happened to Manchester City after they lost their talisman Vincent Kompany and failed to replace him. "When we were walking off, Thiago tells me he thinks he was injured".