Next Wednesday, when Biden will be sworn in as president, marks the one-year anniversary of the first confirmed case of COVID-19 in the United States.
"The crisis of deep human suffering is in plain sight, and there's not time to waste", Biden said.
"At this moment, the president-elect feels that we need to move aggressively on both rescue and recovery", Deese said in a video conference withReuters. "We can not afford inaction".
It includes $415 billion to bolster the response to the virus and the rollout of COVID-19 vaccines, some $1 trillion in direct relief to households, and roughly $440 billion for small businesses and communities particularly hard hit by the pandemic.
Congress included payments of $1,200 in its initial stimulus when shutdowns because of the coronavirus began last spring.
Biden's stimulus proposal builds on two massive relief packages Congress approved in 2020, and both increases and extends through September unemployment benefits that have helped tens of millions of people pay their bills after losing their jobs during the pandemic.
More than 385,000 people have died in the US from COVID-19 since the virus was first identified in the country in early 2020.
With the backing of Congress and the expertise of private and government scientists, the Trump administration has delivered two highly effective vaccines and more are on the way.
Although Trump himself supported $2,000 checks for Americans in the last round of stimulus, many of his fellow Republicans balked at the high amount, settling on $600 checks instead.
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The incoming president will seek to pass the legislation even as his predecessor faces an impeachment trial.
US President Donald Trump arrives on the South Lawn of the White House in Washington after a trip to Texas, January 12, 2021.
Biden expects to propose a second economic recovery plan in coming weeks, aimed at longer-term job creation and development goals such as climate change.
Mr. Biden is also calling for $30 billion in rental, water, and energy assistance, and an extension of a federal eviction and foreclosure moratorium through September.
Some of Biden's key provisions, including the stimulus payments, jobless benefits and US$15 minimum wage, could likely be passed using a fast-track process known as budget reconciliation, which would permit Democrats to pass the bill through the Senate without needing Republican votes.
The coronavirus relief-related funds will go toward a national vaccine program, testing, investments for workers to do vaccine outreach and contact tracing, and money for states.
But Biden's biggest challenge is to "win the hearts and minds of the American people to follow his lead", said Dr. Leana Wen, a public health expert and emergency physician.
"This will be one of the most challenging operations efforts we've ever undertaken as a nation".
The rescue plan includes US$350 billion for state and local governments, more than double the US$160 billion that a number of GOP members had backed late previous year in a bipartisan compromise proposal.