Chauvin, 45, is charged with murder and manslaughter over Floyd's May 25, 2020 death, which sparked protests against racial injustice around the world and is being seen as a landmark test of police accountability.
Nelson said prosecutors were wrong to dismiss his theory that carbon monoxide poisoning from the nearby police car's exhaust and Floyd's use of fentanyl, an opioid painkiller, may have contributed to Floyd's death.
"Believe your eyes", he said.
"It's exactly what you knew, it's what you felt in your gut, it's what you now know in your heart".
With tensions high as a possible verdict nears, two guard members were slightly injured after at least one person opened fire from a vehicle on a team of troops and police early on Sunday in Minneapolis, authorities said.
Derek Chauvin faces murder and manslaughter charges for his role in the death of George Floyd.
The same issues raised by Floyd's death came to the forefront in the community again about a week ago when a now-resigned police officer in a Minneapolis suburb killed a 20-year-old African American man during a traffic stop.
"He did not purposefully use unlawful force".
Mr Wright's killing triggered several nights of protests in Minneapolis and National Guard troops have been deployed in the Minnesota city where shop windows have been boarded up as a precaution.
"We are in touch with local authorities, we are in touch with states, with governors, with mayors", Ms Psaki said.
On Monday, prosecutors and Mr. Chauvin's defense lawyer made their closing arguments for conviction and acquittal, respectively, summing up the evidence. "Hold police officers accountable".
"We want to strike the right balance between allowing people to speak about the trial and what the verdict means, while still doing our part to protect everyone's safety", the company said.
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Presenting his closing arguments, defense attorney Eric Nelson told the jury they need to look at Chauvin's actions "from the perspective of a reasonable police officer".
"They say a picture's worth a thousand words, I think that that video said a million and I think it's going to be very hard for the jury to get that image out of their mind", she said.
Chauvin attended every day of the trial, dressed in a suit and taking notes on a yellow legal pad.
Genevieve Hansen, 27, an off-duty firefighter, said Mr Chauvin and other officers rebuffed her offers to provide medical attention to Mr Floyd.
He defended the actions of Chauvin and the other officers who held Floyd down on the ground. The defense has countered that Mr. Chauvin was reasonably restraining Mr. Floyd when he died of a sudden heart attack fueled by clogged arteries and drugs.
The defense also called a retired police officer who said Chauvin's use of force against Floyd was "justified".
But Nelson said the prosecution brought in experts to testify that Floyd died because of asphyxia, or lack of oxygen, while the person who actually performed the autopsy, the county medical examiner, reached a different finding.
In a statement released after Brodd's testimony, Santa Rosa Police Chief Rainer Navarro distanced himself from his department's former officer.
Chauvin "had to know" he was squeezing the life out of Mr Floyd as he cried over and over that he could not breathe and finally fell silent, a prosecutor told the jury during closing arguments.
If convicted of the most serious charge against him, second-degree murder, Chauvin could face up to 40 years in prison, though state guidelines suggest a sentence of about 12 years for such a charge.
They are to be tried separately later in the year.