Having only recovered from a knee injury, the Argentine striker injured his hamstring in the draw with West Ham United and missed last Saturday's win at Sheffield United and the Champions League trip to Marseille last week.
And ahead of their Group C clash with Olympiacos on Tuesday, Guardiola acknowledged the quest to become European champions seems to become more of a challenge with each passing season.
'We are in an ideal position, ' said Guardiola.
"We don't want him to have a setback but he's getting better". What he felt was not so unsafe.
"I don't know about Liverpool, but I think after the worldwide break he will be ready".
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"It's too early to know".
"He did one with the team [on Sunday]. We're happy with Ferran, we have another alternative".
And Guardiola is keen to mathematically reach the knockout stages as soon as possible to be able to give some key players a rest in November and December with a brutal schedule already taking it's toll on his squad.
The club from the Athens suburb of Piraeus have lost nine of their 10 Champions League games away to English clubs by a combined score of 30 goals to seven and in Manchester specifically, it's even worse: three losses to United at Old Trafford, no goals scored, 10 conceded. "Focus on next game and tomorrow is a huge opportunity for us to make an incredible step".
"Every game is hard". People don't believe me. It's a tricky competition.
"We can not miss this chance to get nine points and be in a position for one more step to be in the 16 better teams in Europe".