Floyd's death led to protests, mostly under the "Black Lives Matter" movement, across the world.
"Derek Chauvin did exactly what he was trained to do over the course of his 19-year career", Mr Nelson told the jury.
Prosecutors say Chauvin is responsible for killing Floyd, but the defense says that Floyd's health issues and drug use aggravated a heart condition and that Chauvin should be absolved.
Chauvin's lawyers have argued that the main cause of Mr Floyd's death was a drug overdose.
Floyd, 46, had none of the telltale signs of asphyxiation and had fentanyl and methamphetamine in his system, Nelson said.
"There is no political or social cause in this courtroom", Nelson said. That evidence is expansive, he said, and is far broader than what they will see in video footage that shows the final 10 minutes of the encounter between Floyd and the police.
Their protest began at 08:46 in Minneapolis, Minnesota, the USA city where Derek Chauvin, 44, is on trial for murder and manslaughter after allegedly pinning Floyd - on his stomach, with his hands cuffed behind his back - to the ground. He faces up to 40 years in prison if convicted on the most serious charge. The case is the first trial ever televised in Minnesota. Scurry said she grew concerned because the officers hadn't moved after several minutes.
She said her instincts told her something was wrong - including the amount of time that police had been in the position they were and the fact they had not asked for backup.
A shop assistant believed he had used a counterfeit $20 bill and called the police after Mr Floyd refused to give the cigarettes back.
Attorney Ben Crump counts off 8 minutes as he takes a knee for 8 minutes and 46 seconds with members of George Floyds family and Rev. Al Sharpton
The incident sparked protests in the United States and across the world against police brutality and racism. Confederate statues and other symbols were pulled down around the USA, and activists demanded that police department budgets be cut or overhauled. Chauvin sat calmly during opening statements and took notes, looking up at the video periodically.
"My stomach hurts", he says.
In a video that has been widely circulated online, he's heard saying "I can't breathe" before he died. Each time she looked up, she testified, the officers were still on top of Floyd. One woman, identifying herself as a city Fire Department employee, shouts at Chauvin to check Floyd's pulse.
The 46-year-old was declared dead after Chauvin, who is white, kept his knee on Mr Floyd's neck as he lay handcuffed on his belly on the pavement. But it was revised during the investigation.
Eight jurors are white and six are Black or multiracial, according to the court. The judge has not said which ones will be alternates and which ones will deliberate the case.
Blackwell said he was not trying to put all police on trial. "She did her best to intervene".
He said Chauvin pointed Mace at her.
George Floyd's family attorney, Ben Crump, reacts to the start of the Derek Chauvin trial exclusively on 'The Story'. So, America, this is the moment, this is the moment to show the rest of the world that you are the standard bearer when it comes to liberty and justice for all.
The courtroom in a tower in downtown Minneapolis was ringed with concrete barriers, barbed wire and soldiers from the state's National Guard.
By that rule, camera's wouldn't have been allowed at Chauvin's trial because Minnesota Attorney General Keith Ellison opposed them on the grounds that they could scare away potential witnesses. Judge Peter Cahill ordered that cameras be allowed largely because of the pandemic and the required social distancing that meant there would be nearly no room for spectators in the courtroom.
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They were also linked to local extremist network Jamaah Ansharut Daulah (JAD), which has pledged allegiance to Islamic State. A report from Kompas TV shows police officers securing the area in front of the church.